Clinically Isolated Syndrome (CIS) Presenting with Ataxia and Ophthalmoplegia

A clinically isolated syndrome is the result of a single episode of demyelination in one area of the central nervous system (a monofocal episode) or several areas of the central nervous system (a multifocal episode) which lasts for at least 24 hours. Of those who are eventually diagnosed with MS, 85% experience an initial onset of symptoms or a first attack that is referred to as a clinically isolated syndrome (CIS). Here we describe a 10-yr-old-boy with ataxia and ophthalmoplegia, whose MRI showed demyelination only in bilateral frontoparietal subcortical areas. Patient improved on pulse methyl-prednisolone therapy with tapering dose of steroids and never had recurrence on further follow up till date. *Corresponding author: Jayitri Mazumdar, Department of Pediatrics, Calcutta National Medical College 176/1 Birji road, Flat no. D2, Kadamtala, Garia, Kolkata, India 700084, Tel: 9407 9407; E-mail: [email protected] Received September 09, 2015; Accepted October 05, 2015; Published October 12, 2015 Citation: Mazumdar J, Kanjilal S, Ghosh KC (2015) Clinically Isolated Syndrome (CIS) Presenting with Ataxia and Ophthalmoplegia. J Mult Scler (Foster City) 2:155. doi:10.4172/2376-0389.1000155 Copyright: © 2015 Mazumdar J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.